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Cagrilintide
Amylin Analog — Long-Acting
Cagrilintide is a long-acting amylin analog designed for once-weekly dosing. Studied for its amylin receptor agonism, satiety signaling, and complementary metabolic effects when combined with GLP-1 receptor agonists.
Research Overview
Cagrilintide (AM833) is a long-acting fatty acid-acylated analog of human amylin, engineered for extended half-life through albumin binding. Amylin is a 37-amino acid peptide co-secreted with insulin from pancreatic beta cells that acts on amylin receptors (AMY1–3) in the area postrema and hypothalamus to regulate satiety, gastric emptying, and glucagon secretion. Research interest in cagrilintide centers on its amylin receptor pharmacology, its complementary and potentially synergistic metabolic effects when combined with GLP-1 receptor agonists (as in the CagriSema combination), and its role in central appetite regulation circuits.
Research Highlights
Related Compounds
View AllSemaglutide
GLP-1 Receptor Agonist
Semaglutide is a long-acting GLP-1 (glucagon-like peptide-1) receptor agonist. Used extensively in metabolic and endocrine research to study insulin secretion, glucagon suppression, and energy homeostasis.
Tirzepatide
Dual GIP/GLP-1 Receptor Agonist
Tirzepatide is a novel dual GIP/GLP-1 receptor agonist. Studied for its combined incretin effects on glucose metabolism, insulin sensitivity, and energy regulation in metabolic research settings.
NAD+
Nicotinamide Adenine Dinucleotide
NAD+ is a critical coenzyme found in all living cells, central to redox reactions and energy metabolism. Studied extensively for its roles in sirtuin activation, DNA repair, and cellular aging research.
For Research Purposes Only · Not intended for human consumption