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PT-141
PT-141 (Bremelanotide)
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist derived from Melanotan II. Studied for its activity at MC3R and MC4R receptors, with research applications in central melanocortin pathway modulation and CNS-mediated signaling studies.
Research Overview
PT-141, also known as Bremelanotide, is a cyclic heptapeptide and synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) derived from Melanotan II. Unlike its parent compound, PT-141 lacks the C-terminal amide group, resulting in a distinct pharmacological profile. It acts as a non-selective melanocortin receptor agonist with activity at MC1R, MC3R, MC4R, and MC5R. Research interest centers on its central nervous system activity via MC3R and MC4R pathways, which are implicated in energy homeostasis, autonomic regulation, and neuroendocrine signaling. PT-141 is a valuable research tool for investigating the central melanocortin axis, receptor subtype selectivity, and CNS-mediated peptide signaling mechanisms.
Research Highlights
For Research Purposes Only · Not intended for human consumption