Age Verification Required
Research Purposes Only
This website contains information about research peptides intended strictly for laboratory and scientific research. You must be 18 years or older to enter.
By entering you confirm you are 18+ and agree that all products are for research use only. Not for human consumption.
ACE-031
ACVR2B-Fc Fusion Protein
ACE-031 is a soluble form of activin receptor type IIB (ACVR2B) fused to an Fc domain. Studied as a myostatin and activin pathway inhibitor in skeletal muscle mass and neuromuscular disease research.
Research Overview
ACE-031 (sotatercept precursor analog) is a recombinant fusion protein consisting of the extracellular domain of activin receptor type IIB (ACVR2B) linked to a human IgG1 Fc region. By acting as a ligand trap, ACE-031 sequesters myostatin (GDF-8), activin A, GDF-11, and other TGF-β superfamily ligands that negatively regulate skeletal muscle mass. It is studied in research models of muscle wasting, Duchenne muscular dystrophy, spinal muscular atrophy, and sarcopenia. ACE-031 has been investigated in clinical trials for its ability to increase lean muscle mass and bone mineral density through ACVR2B pathway inhibition.
Research Highlights
For Research Purposes Only · Not intended for human consumption