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MOTS-c
Mitochondria-Derived Peptide
MOTS-c is a mitochondria-derived peptide encoded within the 12S rRNA gene. Studied for its role in mitochondrial-nuclear communication, metabolic regulation, and cellular stress response pathways.
Research Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome, specifically within the 12S rRNA gene. It represents a novel class of mitochondria-derived peptides (MDPs) that function as retrograde signals from mitochondria to the nucleus. Research has focused on its role in activating AMPK signaling, regulating folate and methionine metabolism, modulating insulin sensitivity, and its translocation to the nucleus under metabolic stress conditions. MOTS-c is a key research tool for studying mitochondrial-nuclear crosstalk and metabolic homeostasis.
Research Highlights
Related Compounds
View AllSemaglutide
GLP-1 Receptor Agonist
Semaglutide is a long-acting GLP-1 (glucagon-like peptide-1) receptor agonist. Used extensively in metabolic and endocrine research to study insulin secretion, glucagon suppression, and energy homeostasis.
Tirzepatide
Dual GIP/GLP-1 Receptor Agonist
Tirzepatide is a novel dual GIP/GLP-1 receptor agonist. Studied for its combined incretin effects on glucose metabolism, insulin sensitivity, and energy regulation in metabolic research settings.
NAD+
Nicotinamide Adenine Dinucleotide
NAD+ is a critical coenzyme found in all living cells, central to redox reactions and energy metabolism. Studied extensively for its roles in sirtuin activation, DNA repair, and cellular aging research.
For Research Purposes Only · Not intended for human consumption