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Retatrutide
Triple Receptor Agonist (GIP/GLP-1/Glucagon)
Retatrutide is a triple GIP/GLP-1/glucagon receptor agonist. Studied for its combined triagonist effects on metabolic regulation, energy expenditure, and glucose homeostasis in laboratory research.
Research Overview
Retatrutide (LY3437943) is a first-in-class triple agonist targeting GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors simultaneously. This triagonist approach is of significant research interest because it combines the insulin-sensitizing and appetite-suppressing effects of GLP-1 and GIP agonism with the energy expenditure-enhancing effects of glucagon receptor activation. In vitro research applications include triple incretin receptor pharmacology, comparative receptor selectivity profiling, adipose tissue lipolysis studies, and investigations into the additive metabolic effects of simultaneous activation of all three receptors.
Research Highlights
Related Compounds
View AllSemaglutide
GLP-1 Receptor Agonist
Semaglutide is a long-acting GLP-1 (glucagon-like peptide-1) receptor agonist. Used extensively in metabolic and endocrine research to study insulin secretion, glucagon suppression, and energy homeostasis.
Tirzepatide
Dual GIP/GLP-1 Receptor Agonist
Tirzepatide is a novel dual GIP/GLP-1 receptor agonist. Studied for its combined incretin effects on glucose metabolism, insulin sensitivity, and energy regulation in metabolic research settings.
NAD+
Nicotinamide Adenine Dinucleotide
NAD+ is a critical coenzyme found in all living cells, central to redox reactions and energy metabolism. Studied extensively for its roles in sirtuin activation, DNA repair, and cellular aging research.
For Research Purposes Only · Not intended for human consumption